Which medication class is often used in ARDS for sedation?

Benzodiazepines are often used for sedation in patients with ARDS due to their anxiolytic, amnesic, and sedative properties. In the context of ARDS, where patients may experience discomfort and anxiety due to invasive mechanical ventilation, benzodiazepines help provide the necessary sedation for both patient comfort and safety during treatment.

They work by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor, leading to sedation and anxiolysis. This class of drugs is preferred in various clinical settings because they allow for easier titration and can be reversed if needed, offering flexibility in a critical care environment.

While opioids may provide analgesia and sedation, they can also lead to respiratory depression, which is a significant concern in ARDS patients who already struggle with gas exchange. Barbiturates, though effective for sedation, are less commonly used today due to their side effects and potential for decreased responsiveness, making them less ideal in a critical care setting. Antipsychotics are not generally indicated for sedation in ARDS and are typically reserved for conditions such as acute agitation or severe psychosis. Therefore, benzodiazepines remain the most appropriate choice for sedation in